Effects of Tetrapleura tetraptera Leaves on Renal Architecture and Haematological Indices in Monosodium Glutamate-Intoxicated Rats

Background and Objective: Medicinal plants have been widely used for the treatment of diseases and Tetrapleura tetraptera, a known medicinal plant is not left out. Renal failure is on the increase and calls for use of natural means for its cure and management are on the rise. This study, therefore, investigated the biochemical effects of Tetrapleura tetraptera leaves on renal architecture and haematological indices in Monosodium Glutamate-Intoxicated rats. Materials and Methods: The biochemical effects of Tetrapleura tetraptera leave on renal architecture and haematological indices in Monosodium Glutamate-Intoxicated rats were determined using standard protocols. The SPSS version 22 was used for the one-way ANOVA analysis. Results: The urea and creatinine concentration of the co-treated groups showed a significant (p<0.05) decrease across all and in this case was in a dose-dependent manner. The extract also showed an increase in the count of White Blood Cells, Packed Cell Volume and Haemoglobin and Red Blood Cells across the co-treated groups. The renal histopathological examination indicated normal blood flow without congestion in the normal and Tetrapleura tetraptera leaves ethanol extract group in contrast to full congestion of the central vein as seen in the monosodium glutamate group. Consequently, reduced congestion as seen in the co-treated groups seemingly confirmed the serum chemistry results against the monosodium glutamate group suggesting ameliorative effects. Conclusion: Tetrapleura tetraptera leaves ethanol extract, improved the haematological indices and ameliorated the effects of the renal thwack as established on monosodium glutamate-intoxicated rats.